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Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

COVID-19 outcomes in people living with HIV: Peering through the waves
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Sales, Thaís Lorenna Souza

; Souza-Silva, Maíra Viana Rego

; Delfino-Pereira, Polianna

; Neves, João Victor Baroni

; Sacioto, Manuela Furtado

; Assis, Vivian Costa Morais de

; Duani, Helena

; Oliveira, Neimy Ramos de

; Sampaio, Natália da Cunha Severino

; Ramos, Lucas Emanuel Ferreira

; Schwarzbold, Alexandre Vargas

; Jorge, Alzira de Oliveira

; Scotton, Ana Luiza Bahia Alves

; Castro, Bruno Mateus de

; Silva, Carla Thais Cândida Alves da

; Ramos, Carolina Marques

; Anschau, Fernando

; Botoni, Fernando Antonio

; Grizende, Genna Maira Santos

; Nascimento, Guilherme Fagundes

; Ruschel, Karen Brasil

; Menezes, Luanna Silva Monteiro

; Castro, Luís César de

; Nasi, Luiz Antônio

; Carneiro, Marcelo

; Godoy, Mariana Frizzo de

; Nogueira, Matheus Carvalho Alves

; Guimarães Júnior, Milton Henriques

; Ziegelmann, Patricia Klarmann

; Almeida, Rafaela Charão de

; Francisco, Saionara Cristina

; Silveira Neto, Sidney Teodoro

; Araújo, Silvia Ferreira

; Avelino-Silva, Thiago Junqueira

; Aliberti, Márlon Juliano Romero

; Pires, Magda Carvalho

; Silva, Eduardo Sérgio da

; Marcolino, Milena Soriano

Clinics

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2023, Volume 78 elocation 100223

Resumo: En | Texto: En | PDF: En

Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.

https://doi.org/10.1016/j.clinsp.2023.100223

Dados de Vida Real sobre o Uso da Hidroxicloroquina ou da Cloroquina Combinadas ou Não à Azitromicina em Pacientes com Covid-19: Uma Análise Retrospectiva no Brasil
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Souza-Silva, Maíra Viana Rego

; Pereira, Daniella Nunes

; Pires, Magda Carvalho

; Vasconcelos, Isabela Muzzi

; Schwarzbold, Alexandre Vargas

; Vasconcelos, Diego Henrique de

; Pereira, Elayne Crestani

; Manenti, Euler Roberto Fernandes

; Costa, Felício Roberto

; Aguiar, Filipe Carrilho de

; Anschau, Fernando

; Bartolazzi, Frederico

; Nascimento, Guilherme Fagundes

; Vianna, Heloisa Reniers

; Batista, Joanna d’Arc Lyra

; Machado-Rugolo, Juliana

; Ruschel, Karen Brasil

; Ferreira, Maria Angélica Pires

; Oliveira, Leonardo Seixas de

; Menezes, Luanna Silva Monteiro

; Ziegelmann, Patricia Klarmann

; Tofani, Marcela Gonçalves Trindade

; Bicalho, Maria Aparecida Camargos

; Nogueira, Matheus Carvalho Alves

; Guimarães-Júnior, Milton Henriques

; Aguiar, Rúbia Laura Oliveira

; Rios, Danyelle Romana Alves

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 9 elocation e20220935

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Despite no evidence showing benefits of hydroxychloroquine and chloroquine with or without azithromycin for COVID-19 treatment, these medications have been largely prescribed in Brazil. Objectives To assess outcomes, including in-hospital mortality, electrocardiographic abnormalities, hospital length-of-stay, admission to the intensive care unit, and need for dialysis and mechanical ventilation, in hospitalized COVID-19 patients who received chloroquine or hydroxychloroquine, and to compare outcomes between those patients and their matched controls. Methods A retrospective multicenter cohort study that included consecutive laboratory-confirmed COVID-19 patients from 37 Brazilian hospitals from March to September 2020. Propensity score was used to select matching controls by age, sex, cardiovascular comorbidities, and in-hospital use of corticosteroid. A p-value <0.05 was considered statistically significant. Results From 7,850 COVID-19 patients, 673 (8.6%) received hydroxychloroquine and 67 (0.9%) chloroquine. The median age in the study group was 60 years (46 - 71) and 59.1% were women. During hospitalization, 3.2% of patients presented side effects and 2.2% required therapy discontinuation. Electrocardiographic abnormalities were more prevalent in the chloroquine/hydroxychloroquine group (13.2% vs. 8.2%, p=0.01), and the long corrected QT interval was the main difference (3.6% vs. 0.4%, p<0.001). The median hospital length of stay was longer in the HCQ/CQ + AZT group than in controls (9.0 [5.0, 18.0] vs. 8.0 [4.0, 14.0] days). There was no statistical differences between groups in intensive care unit admission (35.1% vs. 32.0%; p=0.282), invasive mechanical ventilation support (27.0% vs. 22.3%; p=0.074) or mortality (18.9% vs. 18.0%; p=0.682). Conclusion COVID-19 patients treated with chloroquine or hydroxychloroquine had a longer hospital length of stay, when compared to matched controls. Intensive care unit admission, invasive mechanical ventilation, dialysis and in-hospital mortality were similar.

Resumo Fundamento Apesar da ausência de evidência mostrando benefícios da hidroxicloroquina e da cloroquina combinadas ou não à azitromicina no tratamento da covid-19, esses medicamentos têm sido amplamente prescritos no Brasil. Objetivos Avaliar desfechos, incluindo moralidade hospitalar, alterações eletrocardiográficas, tempo de internação, admissão na unidade de terapia intensiva, e necessidade de diálise e de ventilação mecânica em pacientes hospitalizados com covid-19 que receberam cloroquina ou hidroxicloroquina, e comparar os desfechos entre aqueles pacientes e seus controles pareados. Métodos Estudo multicêntrico retrospectivo do tipo coorte que incluiu pacientes com diagnóstico laboratorial de covid-19 de 37 hospitais no Brasil de março a setembro de 2020. Escore de propensão foi usado para selecionar controles pareados quanto a idade, sexo, comorbidades cardiovasculares, e uso de corticosteroides durante a internação. Um valor de p<0,05 foi considerado estatisticamente significativo. Resultados Dos 7850 pacientes com covid-19, 673 (8,6%) receberam hidroxicloroquina e 67 (0,9%) cloroquina. A idade mediana no grupo de estudo foi 60 (46-71) anos e 59,1% eram mulheres. Durante a internação, 3,2% dos pacientes apresentaram efeitos adversos e 2,2% necessitaram de interromper o tratamento. Alterações eletrocardiográficas foram mais prevalentes no grupo hidroxicloroquina/cloroquina (13,2% vs. 8,2%, p=0,01), e o prolongamento do intervalo QT corrigido foi a principal diferença (3,6% vs. 0,4%, p<0,001). O tempo mediano de internação hospitalar foi maior no grupo usando CQ/HCQ em relação aos controles (9,0 [5,0-18,0] vs. 8,0 [4,0-14,0] dias). Não houve diferenças estatisticamente significativas entre os grupos quanto a admissão na unidade de terapia intensiva (35,1% vs. 32,0%; p=0,282), ventilação mecânica invasiva (27,0% vs. 22,3%; p=0,074) ou mortalidade (18,9% vs. 18,0%; p=0,682). Conclusão Pacientes com covid-19 tratados com cloroquina ou hidroxicloroquina apresentaram maior tempo de internação hospitalar, em comparação aos controles. Não houve diferença em relação a admissão em unidade de terapia intensiva, necessidade de ventilação mecânica e mortalidade hospitalar.

https://doi.org/10.36660/abc.20220935

Resistance of cocoa to Moniliophthora perniciosa – progenitors and progenies selection
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Pires, José Luis

; Melo, Gilson Roberto Pires

; Yamada, Milton Macoto

; Martins, Edna Dora

; Luz, Newman

Revista Ceres

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Set 2022, Volume 69 Nº 5 Páginas 544 - 552

Resumo: En | Texto: En | PDF: En

ABSTRACT Witches' broom, caused by Moniliophthora perniciosa, is the most important cacao disease in Brazil, and the final objective of this study is increasing the level and durability of resistance to this fungus, through the association of different alleles or genes favorable to the character, for the generation of new cocoa varieties. It was conducted, for 10 years, the evaluation of the number of vegetative brooms and cushions brooms per plant, of progenies from a cross breeding scheme in North Carolina II design, with the clones: Be 4, Cepec 89, CSul 7, EEG 29, ICS 98, Oc 67, RB 39 and Scavina 6, as group 1 of progenitors, and CCN 10, CCN 51, Cepec 86, ICS 9, IMC 76, Na 33, P4b, and SGu 54, as group 2. For both groups there were differences in terms of the general combining ability and specific combining ability. Differences among progenitors and among progenies were also found for the tendencies in the evolution of the number of brooms over the evaluation period. And it was possible to increase the level and durability of resistance through the association of alleles or genes favorable to this character, all the three results confirming the original hypothesis.

https://doi.org/10.1590/0034-737x202269050007

Economia Circular e Energias Renováveis: uma análise bibliométrica da literatura internacional
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Alves, Josivan Leite

; Chagas, Milton Jarbas Rodrigues

; Faria, Emília de Oliveira

; Caldeira-Pires, Armando de Azevedo

Interações (Campo Grande)

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Jun 2022, Volume 23 Nº 2 Páginas 267 - 283

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O modelo linear de produção e consumo prejudica o meio ambiente e acelera a escassez de recursos naturais. Em contrapartida, a Economia Circular (EC) surge como modelo que visa manter produtos, componentes e materiais em seu mais alto nível de utilidade e valor o tempo todo. Esta pesquisa busca responder à seguinte questão-problema: como a literatura internacional aborda a relação entre Energias Renováveis e Economia Circular em um contexto industrial? Como objetivo geral, tem-se: identificar, na literatura internacional, como os termos Energias Renováveis e Economia Circular se relacionam no contexto industrial. A metodologia aplicada consistiu em uma revisão sistemática da literatura associada à bibliometria nas bases de dados da Scopus e Web of Science, aplicando os termos: “renewabl* energ*” AND “circular economy” AND “industr*”. Os indicadores bibliométricos foram analisados com o auxílio dos softwares MINITAB e VOSviewer. A partir da amostra final, de 88 artigos, os países que mais se destacaram em número de publicações foram a Itália, seguida pela China, Alemanha e Reino Unido. Notou-se que os anos com maior quantidade de publicações foram 2018, 2019 e 2020, sendo que a primeira publicação surgiu em 2012. Dentre os principais resultados, verificou-se que as pesquisas, em sua maioria, são estudos de casos que diagnosticam uma realidade e propõem soluções eficientes junto aos processos produtivos e a redução de impactos ambientais. Por fim, concluiu-se que a Economia Circular é um modelo progressista de produção e consumo, que respeita a limitação dos recursos naturais, ao passo que atende às necessidades humanas.

Abstract The linear model of production and consumption harms the environment and accelerates the scarcity of natural resources. In contrast, the Circular Economy (EC) emerges as a model that aims to keep products, components, and materials at their highest level of usefulness and value at all times. This research seeks to answer the following problem question: how does international literature approach the relationship between Renewable Energies and Circular Economy in an industrial context? The general objective is: to identify, in the international literature, how the terms Renewable Energy and Circular Economy are related in the industrial context. The applied methodology consisted of a systematic review of the literature associated with bibliometrics in the Scopus and Web of Science databases, applying the terms: “renewabl * energ *” AND “circular economy” AND “industr *”. Bibliometric indicators were analyzed with the aid of the MINITAB and VOSviewer softwares. From the final sample of 88 articles, the countries that stood out the most in the number of publications were Italy, followed by China, Germany, and the United Kingdom. It was noted that the years with the largest number of publications were 2018, 2019, and 2020, with the first publication appearing in 2012. Among the main results, it was found that the researches, in its majority, are case studies that diagnose a reality and propose efficient solutions with the production processes and the reduction of environmental impacts. Finally, it was concluded that the Circular Economy is a progressive model of production and consumption, which respects the limitation of natural resources while meeting human needs.

Resumen El modelo lineal de producción y consumo daña el medio ambiente y acelera la escasez de recursos naturales. Por el contrario, la Economía Circular (CE) surge como un modelo que tiene como objetivo mantener los productos, componentes y materiales en su máximo nivel de utilidad y valor en todo momento. Esta investigación busca dar respuesta a la siguiente pregunta problemática: ¿Cómo aborda la literatura internacional la relación entre Energías Renovables y Economía Circular en un contexto industrial? El objetivo general es: identificar, en la literatura internacional, cómo se relacionan los términos Energía Renovable y Economía Circular en el contexto industrial. La metodología aplicada consistió en una revisión sistemática de la literatura asociada a bibliometría en las bases de datos Scopus y Web of Science, aplicando los términos: “renewabl * energ *” AND “economía circular” AND “industr *”. Los indicadores bibliométricos se analizaron con la ayuda de los softwares MINITAB y VOSviewer. De la muestra final, de 88 artículos, los países que más se destacaron en número de publicaciones fueron Italia, seguido de China, Alemania y Reino Unido. Se observó que los años con mayor número de publicaciones fueron 2018, 2019 y 2020, apareciendo la primera publicación en 2012. Entre los principals resultados, se encontró que las investigaciones, en su mayoría, son estudios de caso que diagnostican una realidad y proponen soluciones eficientes con los procesos productivos y la reducción de impactos ambientales. Finalmente, se concluyó que la Economía Circular es un modelo progresivo de producción y consumo, que respeta la limitación de los recursos naturales, al tiempo que satisface las necesidades humanas.

https://doi.org/10.20435/inter.v23i2.3034

Robotic Process Automation and Machine Learning: a Systematic Review
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Moraes, Carlos Henrique Valério de

; Scolimoski, Josnei

; Lambert-Torres, Germano

; Santini, Mariana

; Dias, André Luiz Alves

; Guerra, Fábio Alessandro

; Pedretti, André

; Ramos, Milton Pires

Brazilian Archives of Biology and Technology

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2022, Volume 65 elocation e22220096

Resumo: En | Texto: En | PDF: En

Abstract The need for companies to seek new techniques that generate productivity gains made them carry out the mapping of their processes using Business Process Management (BPM). Well-mapped processes make it possible to identify repetitive tasks, which can be automated using Robotic Process Automation (RPA), where a computer program mimics the actions of an employee. Furthermore, recent advances in Artificial Intelligence have brought new possibilities to RPA. The systematic review developed aims to raise information on Robotic Process Automation (RPA) integrated with Artificial Intelligence (AI) for autonomously automating work processes.

https://doi.org/10.1590/1678-4324-2022220096

Heterogeneous persistence of Mycobacterium leprae in oral and nasal mucosa of multibacillary patients during multidrug therapy
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Neumann, Arthur da Silva

; Fontes, Amanda Nogueira Brum

; Lopes, Márcia Quinhones Pires

; Suffys, Philip Noel

; Moraes, Milton Ozório

; Lara, Flávio Alves

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220058

Resumo: En | Texto: En | PDF: En

BACKGROUND Leprosy is curable by multidrug therapy (MDT) treatment regimen ranging from six to 12 months. The variable levels of tolerance and adherence among patients can, however, result in treatment failure and the emergence of drug-resistant strains. OBJECTIVES Describe the impact of MDT over Mycobacterium leprae viability in patient’s oral and nasal mucosa along treatment. METHODS Mycobacterium leprae viability was monitored by quantitative polymerase chain reaction (qPCR) quantification of 16S rRNA in lateral and contralateral scrapings of oral and nasal mucosa of 10 multibacillary patients along the initial five months of treatment. FINDINGS The results demonstrated high heterogenicity of M. leprae viability among patients and between nasal and oral samples. Of six patients who presented good adherence and tolerance to the treatment, only four displayed absence of M. leprae viability in both samples three months after the first MDT dose, while for the other two, the absence of M. leprae viability in the oral and nasal cavities was only detected five months after the first dose. MAIN CONCLUSIONS We concluded that qPCR of 16S rRNA for the determination of M. leprae viability in nasal and oral scraping samples could represent an interesting approach to monitor treatment efficacy.

https://doi.org/10.1590/0074-02760220058

Hepatitis B virus genotypes prevalence in patients from hepatology services in Ceará, Brazil
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Cruz, José Napoleão Monte Da

; Villar, Lívia Melo

; Mello, Francisco Campello Do Amaral

; Lampe, Elisabeth

; Hyppolito, Elodie Bomfim

; Lima, José Milton De Castro

; Hyppolito, Silvia Bomfim

; Pires Neto, Roberto Da Justa

; Nicolete, Larissa Deadame De Figueiredo

; Coelho, Ivo Castelo Branco

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0807-2020

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: Hepatitis B virus (HBV) infection is a public health problem; therefore, we aimed to report HBV genotypes in Ceará, Brazil. METHODS: A total of 103 HBsAg-positive samples were subjected to HBV genotyping and subgenotyping. RESULTS: The following genetic compositions of samples were found: F-54% (F2-83.33%), A-40% (A1-65%), D-6%, C2-1%, E-1%, and G-1%. CONCLUSIONS: Some genotypes are only prevalent in certain parts of the world; however, the State of Ceará is a hub for migration and has one of the most important liver transplantation centers in Brazil, which can explain the prevalence of the F genotype.

https://doi.org/10.1590/0037-8682-0807-2020 59 downloads

Robotic Process Automation Extended with Artificial Intelligence Techniques in Power Distribution Utilities
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Pedretti, André

; Santini, Mariana

; Scolimoski, Josnei

; Queiroz, Mauro Henrique Brito de

; Toshioka, Frank

; Rocha Junior, Eloy de Paula

; Pauli Júnior, Nelson de

; Yomura, Marcio Takashi

; Costa, Clayton Hilgemberg da

; Guerra, Fabio Alessandro

; Mulinari, Bruna Machado

; Grando, Flavio Lori

; Mumbelli, Joceleide Dalla Costa

; Costa, Cláudio Inácio Almeida

; Torres, Germano Lambert

; Ramos, Milton Pires

Brazilian Archives of Biology and Technology

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2021, Volume 64 Nº spe elocation e21210217

Resumo: En | Texto: En | PDF: En

Abstract Robotic Process Automation (RPA) is one of the several important techniques currently available for companies in search of performance improvement. The step forward in RPA is its association with Artificial Intelligence for more skilled robots. This scenario is not different in Power Distribution Utilities, in which a multitude of complex processes must be executed over different data sources. Making such situation even more complex, these processes are frequently regulated and subject to audit by external bodies. However, an old question remains: what should be robotized and what should be done by humans? This paper aims at partially answering the question in the context of data analysis tasks used for making decisions in complex processes. The research development is conducted based on an Artificial Intelligence methodology incorporated into one software robot (RPA) which acquires data automatically, treats and analyzes these data, helping the human professional take decisions in the process. It is applied to a real case process that is important for validating the research. Four approaches are tested in the data analysis, but only two are really used. The robot analyzes a series of information from an energy consumption meter. The detection of possible behavior deviations in the meter data is made by comparison with its data series. The robot is capable of prioritizing the detected occurrences in the energy consumption data, indicating to the human operator the most critical situations that require attention. The association of Artificial Intelligence and RPA is viable and can really apport important benefits to the company and teams, valuing human work and bringing more efficiency to the processes.

https://doi.org/10.1590/1678-4324-75years-2021210217 241 downloads

10.

Subspine Hip Impingement: Clinical and Radiographic Results of its Arthroscopic Treatment
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Roos, Bruno Dutra

; Roos, Milton Valdomiro

; Camisa Júnior, Antero

; Lima, Ezequiel Moreno Ungaretti

; Fontana, Mariano Feraboli

; Okamoto, Roger Pires

Revista Brasileira de Ortopedia

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Dez 2020, Volume 55 Nº 6 Páginas 722 - 727

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar os resultados clínicos e radiográficos assim como as complicações relacionadas a pacientes submetidos ao tratamento artroscópico do impacto subespinhal do quadril. Métodos Foram avaliados retrospectivamente 25 pacientes (28 quadris) submetidos ao tratamento artroscópico de impacto subespinhal entre janeiro de 2012 e junho de 2018. O seguimento médio foi de 29,5 meses, e os pacientes foram avaliados clinicamente pelo Harris hip score modificado por Byrd (MHHS), o non-arthritic hip score (NAHS), e quanto à rotação interna e flexão do quadril. Além disso, foram avaliados por exames de imagem: o ângulo center-edge (CE) acetabular, o ângulo alfa, a presença de sinal da parede posterior, o grau de artrose, a presença de ossificação heterotópica do quadril e a classificação de Hetsroni para Impacto Subespinhal. Resultados Observou-se aumento médio pós-operatório de 26,9 pontos para o MHHS, 25,4 para o NAHS (p < 0,0001), 10,5° na rotação interna (p < 0,0024) e 7,9° para flexão do quadril (p < 0,0001). Quanto à avaliação radiográfica, observou-se redução média de 3,3° no ângulo CE e de 31,6° para o ângulo alfa (p < 0,0001). Foram classificados 18 casos (64,3%) como artrose grau 0 de Tönnis e 10 (35,7%) como Tönnis 1. Dois casos (7,1%) apresentaram ossificação grau 1 de Brooker. A maioria dos quadris (n = 15; 53,6%) foi classificada como tipo II de Hetsroni et al. Conclusão No presente estudo, os pacientes submetidos a tratamento artroscópico de impacto subespinhal apresentaram melhora nos aspectos clínicos e nos padrões radiográficos aferidos pós-operatoriamente, com seguimento médio de 29,5 meses.

Abstract Objective To evaluate the clinical and radiographic results as well as complications related to patients undergoing arthroscopic treatment of subspine hip impingement. Methods We retrospectively evaluated 25 patients (28 hips) who underwent arthroscopic treatment of subspine impingement between January 2012 and June 2018. The mean follow-up was 29.5 months, and the patients were evaluated clinically by using the Harris hip score modified by Byrd (MHHS), the non-arthritic hip score (NAHS), and in terms of internal rotation and hip flexion. In addition, the following items were evaluated by imaging exams: the center-edge (CE) acetabular angle, the Alpha angle, the presence of a sign of the posterior wall, the degree of arthrosis, the presence of heterotopic hip ossification, and the Hetsroni classification for subspine impingement. Results There was an average postoperative increase of 26.9 points for the MHHS, 25.4 for the NAHS (p < 0.0001), 10.5° in internal rotation (p < 0.0024), and 7.9° for hip flexion (p < 0.0001). As for the radiographic evaluation, an average reduction of 3.3° in the CE angle and of 31.6° for the Alpha angle (p < 0.0001). Eighteen cases (64.3%) were classified as grade 0 osteoarthritis of Tönnis, and 10 (35.7%) were classified as Tönnis grade 1. Two cases (7.1%) presented grade 1 ossification of Brooker. Most hips (n = 15, 53.6%) were classified as type II of Hetsroni et al. Conclusion In the present study, patients undergoing arthroscopic treatment with subspine impingement showed improvement in clinical aspects and radiographic patterns measured postoperatively, with an average follow-up of 29.5 months.

https://doi.org/10.1055/s-0040-1713760 504 downloads

11.

[SciELO Preprints] - Analysis of the spatial-temporal dynamics of incidence, mortality and test rates (rapid and RT-PCR) of COVID-19 in the state of Minas Gerais, Brazil
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Silva-Júnior, Milton José da Mendonça, Kaio Saramago Lima, Caio Augusto de Pires, Priscilla Larissa Silva Calegari, Tatiany Oliveira, Stefan Vilges de

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Data de publicação: 2020-08-10

Resumo: En

Introduction: A novel type of coronavirus, SARS-CoV-2, is responsible for an unprecedented pandemic with profound socioeconomic consequences. Owing to its recent discovery, the virus that emerged in the Chinese city of Wuhan in December 2019 still represents a great unknown to researchers. This study aims to establish the spatio-temporal associations of the incidence, mortality, and the rate of both rapid and RT-PCR tests in Minas Gerais. Methods: This is a quantitative analysis of secondary data based on a cross-sectional research design. Incidence, mortality, date of the first notification of COVID-19 and number of rapid and RT-PCR tests were obtained from the sources: Laboratory Environment Manager, e-SUS epidemiological surveillance platform and SES-MG. Pearson coefficient for correlation was calculated to establish the level of association between the relevant data. Descriptive statistical procedures were used to provide a comprehensive understanding of the distribution of incidence, mortality and test rates in the territory. Results: Positive correlations were found between the rate of rapid tests and incidence; rate of RT-PCR tests and incidence/mortality. At the municipal level, incidence, mortality, rate of rapid tests and RT-PCR revealed a negative correlation with days elapsed since the First Notified Case. The same effect occurs, at different intensities, at the level of health macro-regions. Discussion: The heterogeneity of the incidence and mortality of COVID-19 in the territory of Minas Gerais, as well as the rate of tests (rapid and RT-PCR) may be caused, in part, due to the different dates of introduction of the virus in the municipalities/macro-regions. It is speculated that this phenomenon occurs due to the dynamics of regional and inter-regional flows of people.

https://doi.org/10.1590/SciELOPreprints.1077

12.

Online learning and COVID-19: a meta-synthesis analysis
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Camargo, Cristina Pires

; Tempski, Patricia Zen

; Busnardo, Fabio Freitas

; Martins, Milton de Arruda

; Gemperli, Rolf

Clinics

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2020, Volume 75 elocation e2286

Resumo: En | Texto: En | PDF: En

The COVID-19 pandemic demanded a quick shift from presential to e-learning processes. Unlike planned e-learning programs, medical schools have had to quickly deliver the entire medical curriculum using remote strategies. This study aimed to perform a meta-synthesis of previous pandemic situations and describe the experience of the São Paulo University School of Medicine. We searched the Cochrane Central Register of Controlled Trials, Medline, EMBASE, Lilacs, Scopus, Web of Science, and ERIC, using the following keywords: (“SARS” OR “severe acute respiratory syndrome” OR “severe acute respiratory syndrome” OR “Middle East Respiratory Syndrome Coronavirus” OR “middle east respiratory syndrome*” OR “MERS-CoV” OR “Mers” OR “Middle Eastern Respiratory Syndrome*” OR “MERS-CoV*” OR “coronavirus” OR “Coronavirus Infections” OR “coronavirus*” OR “COVID-19” OR “2019-nCoV” OR “SARS-CoV-2”) AND (“online education” OR “Education, Distance” OR “e-learning” OR “course online” OR “flipped classroom”) AND (“lockdown” OR “social distance” OR “quarantine”). The endpoints were the online platforms used for online learning, the model of class, recorded versus online interaction, duration of online lectures, and students' and teachers' perceptions of online learning. We retrieved 38 records; only seven articles studied online education methods related to the pandemic and social distancing rules. The most frequently used online platform was Zoom®. The studies examined both synchronous and asynchronous approaches. There was no evidence regarding duration and students’ and teachers' attitude. This study suggests that the online learning shift was feasible; however, because of the nature of the education shift (pandemic), future studies must further analyze the educational structure.

https://doi.org/10.6061/clinics/2020/e2286 3128 downloads

13.

Alkalizing potential and calcium release of residues from intracanal dressing containing calcium hydroxide
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CRESPO, Mariana Pires

; PEREIRA, Kamila de Figueiredo

; KUGA, Milton Carlos

; PORTO, Thiago Soares

; ARMADA, Luciana

Revista de Odontologia da UNESP

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Dez 2018, Volume 47 Nº 6 Páginas 383 - 387

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução Se a restauração temporária, que sela o canal radicular contra o meio bucal, falhar ou solubilizar, a medicação intracanal pode ser parcialmente removida, diminuindo a eficiência do hidróxido de cálcio (CH). Objetivo Avaliar o potencial alcalinizante e a liberação de íons cálcio de resíduos de diferentes medicações intracanal, em diferentes períodos. Material e método Incisivos humanos foram endodonticamente instrumentados e divididos aleatoriamente (n=10). Os canais radiculares foram preenchidos com: G1⎯Hidróxido de cálcio (CH); G2⎯CH com 0.4% de digluconato de clorexidina (CHC); G3⎯CH com paramonoclorofenol camforado e glicerina (HPG); G4⎯CH mantido durante todo experimento, como controle positivo (PC) e G5⎯Sem medicação intracanal, como controle negativo (NC). Os espécimes foram imersos em água destilada durante 7 dias. A medicação intracanal foi removida dos grupos experimentais com um instrumento F1 (Protaper). Os dentes foram armazenados em água destilada por 24 horas, 7, 14 e 28 dias. Os dados foram submetidos aos testes ANOVA one-way e Tukey. Resultado Todos os grupos experimentais tiveram redução no potencial alcalinizante e na liberação dos íons cálcio, quando comparados ao controle positivo (p<0.05). Não houve diferença estatisticamente significante entre os grupos experimentais, independente do período (p>0.05). Conclusão O potencial alcalinizante e a liberação de íons cálcio dos resíduos de diferentes medicações intracanal, em diferentes períodos, foram similares entre si e menores que o controle positivo, onde a medicação foi mantida dentro do canal radicular, encorajando a sua troca quando a restauração falhar.

Abstract Introduction If the restoration, that seal the root canal from oral environment, failed or solubilize, the intracanal dressing could be partially removed, decreasing the efficiency of calcium hydroxide (CH). Objective To evaluate the alkalizing potential and calcium ions release of intracanal residues from different medications, in different periods. Materials and method Human incisors were endodontically instrumented and randomly divided (n=10). The root canals were filled with: G1⎯Calcium hydroxide (CH); G2⎯CH with 0.4% chlorhexidine digluconate (CHC); G3⎯CH with camphorated paramonochlorophenol and glycerin (HPG); G4⎯CH was maintained during all experiment, as positive control group (PC) and G5⎯ No medication was performed in the negative control group (NC). The specimens were immersed in distilled water for 7 days. The intracanal dressing was removed from the experimental groups using F1 instrument (Protaper). The teeth were stored in distilled water for 24 hours, 7, 14 and 28 days. pH value and calcium ions released were evaluated and the data were submitted to ANOVA one-way and Tukey tests. Result All experimental groups presented lower alkalizing potential and calcium ions release than PC (P<0.05). No significant difference was found among the experimental groups, regardless of the period (P>0.05). Conclusion The alkalizing potential and calcium ions release of residues from different intracanal dressing, in different periods, were similar and lower than the positive control group, that the medication was maintained inside the root canal, encouraging the replacement of intracanal dressing when the restoration fail.

https://doi.org/10.1590/1807-2577.11018 757 downloads

14.

Winter cover crops affecting physical and chemical soil attributes in a commercial vineyard
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Veiga, Milton da

; Feldberg, Nelson Pires

; Nava, Gilberto

; Bettoni, Jean Carlos

Ciência Rural

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Dez 2017, Volume 47 Nº 12 elocation e20160827

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

ESUMO: As plantas de cobertura podem apresentar efeitos diretos ou indiretos sobre os atributos físicos e químicos do solo, desempenhando papel fundamental na ciclagem dos nutrientes e na adição de carbono orgânico lábil ao solo, trazendo benefícios econômicos e ecológicos ao sistema. Para estudar o efeito de plantas de cobertura sobre os atributos físicos e químicos de um Nitossolo Vermelho, foi conduzido por três anos um experimento com semeadura de diferentes espécies de inverno (trevo-branco, trevo-vermelho, ervilhaca-comum, nabo-forrageiro, espérgula, aveia-preta, centeio e azevém), além dos tratamentos com capina manual e roçada mecânica, em um vinhedo comercial localizado na Estação Experimental da Epagri em Videira, SC. Foram determinados alguns atributos químicos e físicos do solo em amostras coletadas nas camadas de 0-0,1 e 0,1-0,2m de profundidade na linha e na entrelinha da cultura, além da massa seca das plantas de cobertura de inverno. As plantas de cobertura do solo alteram poucos atributos químicos e físicos do solo e não se diferenciam do manejo da vegetação espontânea com capinas manuais ou com roçadas mecânicas. A linha da cultura apresenta valores mais adequados da maioria dos atributos físicos e químicos do solo.

ABSTRACT: Cover crops may have direct or indirect effects on the physical and chemicalsoil attributes; these cropsplay a key role in the cycling of nutrients in the soil and add labile organic carbon, bringing economic and environmental benefits to the system. To study the effect of cover crops on the physical and chemical properties of an Oxisol, a three-year experiment was conducted in a commercial vineyard located at Epagri’s Experimental Station in Videira, SC, Brazil. Different winter species (white clover, red clover, common vetch, turnip, corn spurrey, black oat, rye, and ryegrass) were sown in addition to treatments with manual weeding or mechanical mowing. Certain chemical and physical attributes of soil were determined in samples collected fromlayers 0-0.1 and 0.1-0.2m deep on the vinerows and between rows, as well as the dry mass of winter cover crops. Few chemical and physical attributes of the soil changed among winter cover crops and did not differ from the crops managed with mechanical mowing or hand weeding of spontaneous vegetation. Vine rows provided more adequate values of most physical and chemical soil attributes.

https://doi.org/10.1590/0103-8478cr20160827 1319 downloads

15.

Compulsory notification at skilled nursing facilities
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Gorzoni, Milton Luiz

; Aguado, Márcia Regina Valadares

; Pires, Sueli Luciano

; Faria, Lilian de Fátima Costa

Revista da Associação Médica Brasileira

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Mai 2017, Volume 63 Nº 5 Páginas 447 - 451

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Doenças de notificação compulsória (DNC) abrangem quadros de alta gravidade clínica e/ou de contágio. Sendo comunidades fechadas, instituições de longa permanência para idosos (ILPI) são locais que merecem atenção quanto a elas. Mas qual seria a realidade das DNC em ILPI brasileiras? Objetivo: Determinar prevalência e tipo de DNC em ILPI de grande porte. Método: Busca ativa de DNC pela Comissão de Controle de Infecção Hospitalar (CCIH) em 459 leitos. Em razão da baixa rotatividade de pacientes, analisou-se lista mensal da CCIH sobre DNC. Dividiram-se os dados entre homens e mulheres e entre idosos (idade ≥ 60 anos) e não idosos (idade ≤ 59 anos). Resultados: 31 doenças em 29 pacientes (6,9% do total de internados - 19 homens e 10 mulheres): 23 casos de hepatite C, cinco de hepatite B, dois de positividade sorológica ao vírus da imunodeficiência humana (HIV) e um caso de tuberculose renal. Um paciente com hepatite B e outro com HIV positivo eram também portadores de hepatite C. Não houve significância estatística quando foram comparados os dois grupos com o total dos outros internados - por idade e gênero - pelo total de DNC e nos casos de hepatite C (p>0,05). Conclusão: Pesquisa em 15/11/2008 no portal http://www.scielo.br/não detectou casuísticas em ILPI, exceto por revisões sobre tuberculose. DNC de caráter e/ou tratamento crônico observadas neste estudo sugerem a necessidade de maior número de publicações para definir a dinâmica dessas doenças em ILPI brasileiras.

Summary Introduction: Notifiable diseases (NDs) encompass conditions of high clinical severity and/or contagious. Being closed communities, long-term care facilities (LTCF) are places that deserve attention on their own, but one might be left wondering: what is the reality of NDs at Brazilian LTCFs? Objective: To determine the prevalence and type of NDs at large LTCF. Method: Active search for NDs conducted by the Hospital Infection Control Committee (HICC) in 459 beds. Due to the low turnover of patients, the monthly list kept by the HICC on NDs was analyzed. Data were grouped into males and females, and into elderly (age ≥ 60 years) and non-elderly (age ≤ 59 years). Results: 31 diseases in 29 patients (6.9% of all inpatients - 19 males and 10 females): 23 cases of hepatitis C, five of hepatitis B, two of human immunodeficiency virus (HIV), and one case of renal tuberculosis. One patient with hepatitis B and another HIV-positive also had hepatitis C. There was no statistical significance in the comparison of the two groups with the total number of other institutionalized patients - by age and gender - for total number of NDs and cases of hepatitis C (p>0.05). Conclusion: Chronic NDs and those requiring chronic treatment observed in this study suggest that Brazil needs more studies to define the dynamics of these diseases at LTCFs.

https://doi.org/10.1590/1806-9282.63.05.447 1336 downloads

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